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Symbol
Name
ID 		Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798
Phenotype annotations related to renal/urinary system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Hypercalciuria
Tubulointerstitial nephritis
Nephrocalcinosis
Nephrolithiasis
Renal insufficiency
Disease(s) Associated with PTGS2
cystic fibrosis
sarcoidosis

Mouse Phenotypes
renal/urinary system phenotype
kidney cyst
kidney cortex cyst
kidney corticomedullary cyst
renal glomerulus cyst
abnormal urine homeostasis
decreased urine prostaglandin level
increased urine prostaglandin level
albuminuria
kidney inflammation
pyelonephritis
tubulointerstitial nephritis
abnormal kidney morphology
abnormal kidney capsule morphology
abnormal kidney collecting duct morphology
abnormal kidney cortex morphology
abnormal podocyte morphology
podocyte foot process effacement
increased renal glomerulus basement membrane thickness
abnormal renal glomerulus morphology
abnormal glomerular mesangium morphology
cortical renal glomerulopathies
glomerulosclerosis
decreased renal glomerulus number
renal glomerulus fibrosis
renal glomerulus hypertrophy
kidney cortex atrophy
abnormal kidney corticomedullary boundary morphology
abnormal kidney development
abnormal kidney mesenchyme morphology
abnormal nephrogenic zone morphology
renal interstitial fibrosis
abnormal kidney papilla morphology
kidney medulla hypoplasia
decreased kidney weight
small kidney
renal tubule atrophy
decreased nephron number
abnormal renal tubule morphology
abnormal proximal convoluted tubule morphology
proximal convoluted tubule brush border loss
dilated renal tubule
renal tubule hypertrophy
renal cast
granular kidney
kidney degeneration
nephrocalcinosis
pale kidney
decreased renal glomerular filtration rate
kidney failure
Availability Mouse Genotype
Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Ptgs2tm1.1Wls/Ptgs2tm1.1Wls *
Ptgs2tm1Fun/Ptgs2tm1Fun
Ptgs2tm1Jed/Ptgs2tm1Jed *
Ptgs2tm1Unc/Ptgs2tm1Unc * ! !
Ptgs2tm3Fun/Ptgs2tm3Fun *
Tg(Nphs1-Ptgs2)14Rhrs/0
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory